Trastuzumab in pregnancy associated with poor fetal outcome

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Trastuzumab in pregnancy associated with poor fetal outcome.

Trastuzumab (Herceptin ), an mAb targeting the epidermal growth factor receptor HER2, is used as standard of care in patients with HER2-overexpressing tumors. A relevant number of younger women with childbearing potential are being treated with this immunoglobulin (IgG1) antibody. We report a patient with metastatic breast cancer who was treated with trastuzumab during pregnancy. The baby was b...

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Thrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History

Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...

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Evaluation of Outcome of Mothers with Breast Cancer during Pregnancy, Fetal and Neonatal Development

uction:Breast cancer is the most common cancer in pregnant and non-pregnant women. It also occurs in one out of 3000 to 10000 delivery. The aim of this study is the evaluation of peri-natal and maternal outcome in women with pregnancy associated breast cancer. Method:case series were reviewed retrospectively, which included 9 pregnant women diagnosed with cancer in shahid sadoughi hospital fro...

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Teenage pregnancy and fetal outcome

Background: pregnancy in teenagers is not free of risks. The risk of low birth weight (LBW) and preterm delivery is particularly high among teenagers. LBW is significantly higher in young teenagers aged 13–19 years. Objectives: Evaluation of fetal outcome in teenage pregnancy in Assiut governorate, Egypt. Patients and methods: This study was conducted in the department of obstetrics and gynecol...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2008

ISSN: 0923-7534

DOI: 10.1093/annonc/mdm542